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MTOR regulates endocytosis and nutrient transport in proximal tubular cells

Grahammer, Florian ; Ramakrishnan, Suresh K. ; Rinschen, Markus M. ; Larionov, Alexey A. ; Syed, Maryam ; Khatib, Hazim ; Roerden, Malte ; Sass, Jörn Oliver ; Helmstaedter, Martin ; Osenberg, Dorothea ; Kühne, Lucas ; Kretz, Oliver ; Wanner, Nicola ; Jouret, Francois ; Benzing, Thomas ; Artunc, Ferruh ; Huber, Tobias B. ; Theilig, Franziska

In: Journal of the American Society of Nephrology, 2016, p. -

Renal proximal tubular cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine. Although most of the transport mechanisms have been discovered at the molecular level, little is known about the factors regulating these processes. Here, we show that mTORC1 and mTORC2 specifically and synergistically regulate PTC endocytosis and transport processes. Using a...